In Arkham Travel Guide, you become a guide and create tour routes through the grim and narrow streets of Arkham, full of Curio shops, mysterious Gates and Horrible places. During the game, players roll and collectively choose dice that determine where players can draw tourists and chart routes.

Your goal is to create a route with as many tourists and landmarks of different types as possible, as they score you victory points. Before the end of the game, you will be confronted by the Old One. Depending on how well you avoided Horrible places and used special abilities provided by otherworldly creatures, you either gain rewards or lose tourists.

At the end of the game, tourists and attractions in city blocks along your route earn you victory points. You also get victory points for Personal Objectives and Old Ones' rewards. The player with the most victory points wins the game!